Annual Research & Review in Biology

Fish possess a unique immune system that, while somewhat similar to mammals, exhibits distinct characteristics. This review paper explains the complexities of fish immunity, highlighting the innate and adaptive immune responses that protect against various pathogens, including bacteria (Aeromonas spp, Flavobacterium columnare, Mycobacterium marinum, Streptococcus iniae, Edwardsiella tarda, Pseudomonas aeruginosa etc), viruses (Infectious Hematopoietic Necrosis Virus (IHNV), Viral Hemorrhagic Septicemia Virus (VHSV) etc.), fungi and parasites (Dioctophyma renale etc). Host-pathogen interactions are dynamic and critical for understanding the immune evasion strategies employed by pathogens, such as antigenic variation, molecular mimicry and biofilm formation. Vaccination is crucial in aquaculture, enhancing fish immunity against diseases through various vaccines, including inactivated, live, subunit, and nucleic acid vaccines. Various delivery methods are employed to maximize immunogenic responses, such as injection, immersion, and oral administration. Additionally, advancements in science and technology have led to innovative techniques to increase vaccine efficacy, including nanoparticle delivery and microencapsulation. Successful vaccination strategies have been adapted to combat significant fish pathogens, demonstrating the potential for enhancing disease resistance in aquaculture. This comprehensive overview underscores the importance of understanding fish immune systems and developing effective vaccination strategies to ensure fish health and sustainability in aquaculture practices.